A tri-modal molecular imaging agent for sentinel lymph node mapping

Fluorescent-labeled tilmanocept can be radiolabeled with 68Ga and 99mTc by the sequential addition of each generator eluate to a lyophilized kit. The resulting tri-modal agent provides: PET images for pre-operative SLN mapping, fluorescence imaging up to 72 hours after injection, and quantitative radiometric measurement of SLN accumulation after excision.