Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors

68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2 can be easily synthesized and are both promising candidates for PET imaging of integrin αVβ3 positive tumor cells. 68Ga-NODAGA-E[c(RGDyK)]2 showed slightly more stable tumor retention. With the advantage of in-house commercially 68Ge/68Ga generators, 68Ga-NODAGA-E[c(RGDyK)]2 may be the best choice for future clinical PET imaging in humans.