Antilipolytic drug boosts glucose metabolism in prostate cancer

In mice with PC3 PCa xenografts, acute administration of Acipimox increases tumor uptake of 18 F-FDG with general improvements in tumor-to-background ratios. Data indicate that administration of Acipimox prior to 18 F-FDG PET scans has potential to improve sensitivity and specificity in patients with castration-resistant advanced PCa.