کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10916324 1090274 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography
چکیده انگلیسی
We performed preclinical and clinical studies of O-[11C]methyl-l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 32, Issue 3, April 2005, Pages 253-262
نویسندگان
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