کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10916324 | 1090274 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography](/preview/png/10916324.png)
چکیده انگلیسی
We performed preclinical and clinical studies of O-[11C]methyl-l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 32, Issue 3, April 2005, Pages 253-262
Journal: Nuclear Medicine and Biology - Volume 32, Issue 3, April 2005, Pages 253-262
نویسندگان
Kiichi Ishiwata, Hideo Tsukada, Kazuo Kubota, Tadashi Nariai, Norihiro Harada, Kazunori Kawamura, Yuichi Kimura, Keiichi Oda, Ren Iwata, Kenji Ishii,