کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10916330 1090274 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Purification of cyclotron-produced 203Pb for labeling Herceptin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Purification of cyclotron-produced 203Pb for labeling Herceptin
چکیده انگلیسی
A simple and rapid procedure was developed for the purification of cyclotron-produced 203Pb via the 203Tl(d,2n) 203Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify 203Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified 203Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the 203Pb radioimmunoconjugate were evaluated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 32, Issue 3, April 2005, Pages 301-305
نویسندگان
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