کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10916333 | 1090275 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker](/preview/png/10916333.png)
چکیده انگلیسی
One of the research challenges in oncology is to develop new biochemical methods for noninvasive tumor therapy evaluation to determine whether the chemotherapeutics is effective. Vascular endothelial growth factor (VEGF) was labeled with radioiodine and evaluated in vitro as well as in vivo, using A2058, a melanoma cell line overexpressing VEGFR-1 and -2. Saturation binding analysis with [125I]-VEGF resulted in a Kd of 0.1 nM. Internalization assays indicate the preserved ligand induced internalization and metabolization of the tracer. Biodistribution studies with [123I]-VEGF in wild type and A2058 tumor-bearing athymic mice showed low background activity and a tumor to reference tissue ratio of maximum 6.12. These results suggest that [123I]-VEGF is a potentially suitable tracer for tumor therapy evaluation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 32, Issue 5, July 2005, Pages 431-436
Journal: Nuclear Medicine and Biology - Volume 32, Issue 5, July 2005, Pages 431-436
نویسندگان
Bart Cornelissen, Ruth Oltenfreiter, Veerle Kersemans, Ludovicus Staelens, Francis Frankenne, Jean-Michel Foidart, Guido Slegers,