کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10916361 1090276 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential of [11C]DASB for measuring endogenous serotonin with PET: binding studies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Potential of [11C]DASB for measuring endogenous serotonin with PET: binding studies
چکیده انگلیسی
The serotonin transporter radioligand [11C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, or [11C]DASB, was examined in order to assess its potential for measuring fluctuations in endogenous serotonin concentrations with positron emission tomography. Binding characteristics of [11C]DASB and the propensity for serotonin to displace the tracer were explored in rat brain homogenates. Experiments showed that serotonin displaced [11C]DASB in vitro. Ex vivo experiments performed after tranylcypromine injection (3 or 15 mg/kg) showed a dose-dependent trend in radioactivity uptake and suggested that serotonin may compete with [11C]DASB for transporter binding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volume 32, Issue 2, February 2005, Pages 129-136
نویسندگان
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