کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940846 | 1095524 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection
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کلمات کلیدی
iNKTTH17 responseGATA-binding protein 3IL-23 receptorIL-23RCLRsLTIRORγtSporotrichosisSporothrix schenckiiILCDCsi.p.GATA-3FOXP3T-box expressed in T cells - T-box در سلول های T بیان می شودT-bet - تی شرط بندیforkhead box P3 - جعبه جعبه P3intraperitoneal - داخل صفاقیTh17 cell - سلول Th17innate lymphoid cell - سلول لنفاوی ذاتیDendritic cells - سلول های دندریتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection](/preview/png/10940846.png)
چکیده انگلیسی
The discovery of Th17 cells, along with many other Th cell subsets in the recent years, has expanded the Th1/Th2 paradigm that had persisted since its proposition by Mosmann in 1986. Defined by the characteristic expression of the transcription factor retinoic-related orphan receptor γt (RORγt) and production of IL-17A (IL-17), Th17 cells are powerful inducers of tissue inflammation with a recognized role against extracellular bacteria and fungi. Despite this, the interest in their study came from the pivotal role they play in the development and maintenance of major chronic inflammatory conditions such as multiple sclerosis, rheumatoid arthritis and Crohn's disease, hence they have been the target of promising new anti-Th17 therapies. Accordingly, the identification of opportunistic pathogens whose clearance relies on the Th17 response is of huge prophylactic importance. As shown here for the first time, this applies to Sporothrix schenckii, a thermo-dimorphic fungus and the causative agent of sporotrichosis. Our results show that both Th17 and Th1/Th17 mixed cells are developed during the S. schenckii systemic mice infection, which also leads to augmented production of IL-17 and IL-22. Also, by using an antibody-mediated IL-23 depletion model, we further demonstrate that optimal fungal clearance, but not survival, depends on an intact Th17 response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 220, Issue 8, August 2015, Pages 985-992
Journal: Immunobiology - Volume 220, Issue 8, August 2015, Pages 985-992
نویسندگان
Lucas Souza Ferreira, Amanda Costa Gonçalves, Deivys Leandro Portuondo, Danielle Cardoso Geraldo Maia, Marisa Campos Polesi Placeres, Alexander Batista-Duharte, Iracilda Zeppone Carlos,