کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940954 | 1095535 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Receptor activating NF-κB ligand (RANKL) is a constitutive intracellular protein in resting human basophils and is strongly induced on their surface by interleukin 3
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کلمات کلیدی
PDCTNFSF11RANKLPlasmacytoid DCTRAPOPGMoDCBDCAHprtTRANCETNF-related activation-induced cytokineMonocyte-derived DC - DC مونوسیت مشتق شدهBlood dendritic cell antigen - آنتی ژن سلول دندریتیک خونOsteoprotegerin - استئوپروتگرینtartrate-resistant acid phosphatase - اسید فسفاتاز مقاوم در برابر تارتاتInterleukin-3 - اینترلوکین-3basophils - بازوفیل هاPeripheral blood - خون محیطیRank - رتبهDendritic cells - سلول های دندریتیکRANK ligand - لیگاند RANKHypoxanthine–guanine phosphoribosyltransferase - هیپوکسانتین-گوانین فسفریبوسیل ترانسفرازLymph node - گره های لنفاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Receptor activating NF-κB ligand (RANKL) is a constitutive intracellular protein in resting human basophils and is strongly induced on their surface by interleukin 3 Receptor activating NF-κB ligand (RANKL) is a constitutive intracellular protein in resting human basophils and is strongly induced on their surface by interleukin 3](/preview/png/10940954.png)
چکیده انگلیسی
Receptor activating NF-κB ligand (RANKL) is a member of the TNF superfamily that plays a pivotal role in bone homeostasis as being the major osteoclastogenesis factor. RANKL also has pleiotropic effects in the immune system in which it is expressed by activated T and B cells and some innate lymphoid cells. RANKL-RANK interactions mediate lymph node organogenesis and immunoregulatory functions in autoimmune disease and carcinogenesis as well as cross talk between the immune system and bone. In this study, we show that basophils were the strongest RANKL mRNA-expressing cells amongst major leukocyte subsets in human blood. RANKL was preformed as an intracellular protein in resting basophils and was rapidly and strongly expressed on their surface upon stimulation with IL-3, but not other stimuli. This expression was stable for at least 6 days. Activated basophils could also release soluble RANKL in small quantities upon interaction with DCs or monocytes. In the blood, basophils were the sole cells to express membrane RANKL in response to IL-3. This study indicates that basophils should be considered as new players in the pleiotropic and complex RANKL-RANK interaction system and suggests a role for RANKL in the interaction between basophils and immune cells in inflammatory allergic tissues and secondary lymphoid organs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 220, Issue 5, May 2015, Pages 692-700
Journal: Immunobiology - Volume 220, Issue 5, May 2015, Pages 692-700
نویسندگان
Caroline Poli, Jérôme C. Martin, Cécile Braudeau, Gaelle Bériou, Caroline Hémont, Céline Charrier, Sarah Guérin, Michèle Heslan, Régis Josien,