کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940990 | 1095540 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo](/preview/png/10940990.png)
چکیده انگلیسی
The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphocyte antigen-4 (CTLA-4), glucocorticoid-induced TNFR family-related gene (GITR), Helios and neuropilin-1 (NRP-1) as well as forkhead box protein 3 (FOXP3) were specifically expressed by these CD83+ T cells. In contrast, CD83â T cells showed a naive T cell phenotype with effector T cell properties upon activation. Noteworthy, CD83â T cells were not able to upregulate CD83 despite activation. Furthermore, CD83+ T cells suppressed the proliferation and inflammatory cytokine release of CD83â T cells in vitro. Strikingly, stimulated CD83+ T cells released soluble CD83 (sCD83), which has been reported to possess immunosuppressive properties. In vivo, using the murine transfer colitis model we could show that CD83+ T cells were able to suppress colitis symptoms while CD83â T cells possessed effector functions. In addition, this CD83 expression is also conserved on expanded human Treg. Thus, from these studies we conclude that CD83+ T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 220, Issue 2, February 2015, Pages 270-279
Journal: Immunobiology - Volume 220, Issue 2, February 2015, Pages 270-279
نویسندگان
Simon Kreiser, Jenny Eckhardt, Christine Kuhnt, Marcello Stein, Lena Krzyzak, Christine Seitz, Christine Tucher, Ilka Knippertz, Christoph Becker, Claudia Günther, Alexander Steinkasserer, Matthias Lechmann,