Lymphotoxin-beta receptor expression and its related signaling pathways govern dendritic cell homeostasis and function

Dendritic cells (DCs) play a fundamental function, either positive or detrimental, in regulating immune responses. Numerous specialized DC subsets exist in different organs. However, the trophic factors regulating their origin, location, homeostasis and functions remains to be fully understood. Recent evidence indicates that signaling via the lymphotoxin β receptor (LTβR) can function as a trophic signaling system for specific DCs. LTβR is part of a complex signaling network that provides both positive and inhibitory signals to DC subsets. In this review, we focus on the role of LTβR expressed in DC subsets and its associated signaling pathways that regulate DC homeostasis and function. Therapeutically targeting the LTβR signaling pathway could support the development of a beneficial immune response for the host.