کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10941068 | 1095563 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokine secretion in macrophages and other cells: Pathways and mediators
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کلمات کلیدی
LPStumor necrosis factor alpha converting enzymeTNFSNAREsTGNRegulated upon Activation, Normal T cell Expressed and SecretedTACETLR4vesicle associated membrane proteinVAMPTGFSNAREIFN-γIL-6CTLGFPEndosomes - اندوسومimmunoglobulin - ایمونوگلوبولینinterleukin - اینترلوکینinterleukin 6 - اینترلوکین 6transforming growth factor - تبدیل فاکتور رشدtumour necrosis factor alpha - تومور نکروز عامل آلفاCytokines - سیتوکین هاTrans Golgi Network - شبکه Trans GolgiMIF - شهرSNAP - ضربه محکم و ناگهانیMacrophage migration inhibitory factor - عامل مهارکننده مهاجرت ماکروفاژCytotoxic T lymphocytes - لنفوسیت های T سیتوتوکسیکlipopolysaccharide - لیپوپلی ساکاریدRANTES - مطالبgreen fluorescent protein - پروتئین فلورسنت سبزInterferon gamma - گاما اینترفرونGranules - گرانولToll-like receptor 4 - گیرنده تله مانند 4
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytokine secretion in macrophages and other cells: Pathways and mediators Cytokine secretion in macrophages and other cells: Pathways and mediators](/preview/png/10941068.png)
چکیده انگلیسی
Cytokines and other immune mediators are secreted by cells of the immune system during immune responses and as a means of communication. While the functions of these cytokines, chemokines and mediators are well known, the intracellular pathways that lead to their secretion by different cells are only now being fully documented. Cytokines in some cells are released from secretory granules while in other cells they are released via constitutive secretory pathways that instead have more dynamic vesicular carriers. Recent studies have revealed that newly synthesized cytokines can be routed via compartments such as recycling endosomes prior to their secretion. Here we describe and show examples of some of the pathways used for cytokine trafficking and release in macrophages, including some of the cellular machinery required for this transport. Increasingly, these trafficking pathways are revealed as having important regulatory roles in the execution of immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 214, Issue 7, July 2009, Pages 601-612
Journal: Immunobiology - Volume 214, Issue 7, July 2009, Pages 601-612
نویسندگان
Jennifer L. Stow, Pei Ching Low, Carolin Offenhäuser, Daniele Sangermani,