کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10941073 | 1095567 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activating transcription factor 3 (ATF3) promotes sublytic C5b-9-induced glomerular mesangial cells apoptosis through up-regulation of Gadd45α and KLF6 gene expression
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کلمات کلیدی
ECMDOXPCNAGMCsATF3ATSGADD45αKLF6Proliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیchromatin immunoprecipitation - ایمن سازی کروماتینHIS - خودanti-thymocyte serum - سرم ضد تیمیسیتهglomerular mesangial cells - سلول های مزانژی گلومرولیKrüppel-like factor 6 - عامل کریپول مانند 6activating transcription factor 3 - فعال کردن عامل رونویسی 3Extracellular matrix - ماتریکس خارج سلولیCHiP - چیپMesangioproliferative glomerulonephritis - گلومرولونفریت Mesangioproliferative
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The sublytic C5b-9 complexes can result in glomerular mesangial cells (GMCs) apoptosis, which involved in the initiation and development of rat Thy-1 nephritis. Activating transcription factor 3 (ATF3) is an immediate early gene for cells to cope with a variety of stress signals, and our previous study revealed that ATF3 could promote GMCs apoptosis attacked by sublytic C5b-9. But the mechanism of ATF3 promoting GMCs apoptosis triggered by sublytic C5b-9 attack has not been elucidated. In this study, the data showed that the expression of ATF3, growth arrest and DNA damage-45 alpha (Gadd45α), Krüppel-like factor 6 (KLF6) and proliferating cell nuclear antigen (PCNA) in the GMCs in response to sublytic C5b-9 stimulation for the indicated time was significantly increased, and ATF3 expression could lead to GMCs apoptosis through up-regulation of Gadd45α and KLF6, but not up-regulation of PCNA. Furthermore, Gadd45α was identified as a downstream target gene regulated by ATF3 directly, and KLF6 might be regulated by ATF3 in an indirect manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 216, Issue 8, August 2011, Pages 871-881
Journal: Immunobiology - Volume 216, Issue 8, August 2011, Pages 871-881
نویسندگان
Kuanfeng Xu, Ying Zhou, Wen Qiu, Xin Liu, Mei Xia, Lisha Liu, Xiaomei Liu, Dan Zhao, Yingwei Wang,