کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10941117 | 1095601 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-17A is involved in enhancement of tumor progression in murine intestine
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
mAbMLNs.c.APCMonoclonal antibody - آنتی بادی مونوکلونالAnti-tumor immunity - ایمنی ضد تومورinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینInterleukin-17A - اینترلوکین 17ARecombinant - بازسازی کنندهIntestine - رودهsubcutaneous - زیر جلدیknockout mouse - ماوس نابود شدهi.c. - مدار مجتمع.Gene knock-out - نابودی ژنTumor progression - پیشرفت تومورmesenteric lymph node - گره لنفاوی مزانتریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Interleukin (IL)-17A is a cytokine involved in neutrophilic inflammation but the role of IL-17A in anti-tumor immunity is controversial because both pro- and anti-tumor activities of IL-17A have been reported. We hypothesized that constitutive expression of IL-17A in intestinal environment modifies tumor growth. To address the issue, mice were inoculated into subserosa of cecum (i.c.) with murine EL4 lymphoma expressing a model tumor antigen, and tumor growth was monitored. IL-17A-producing cells were detected both in tumor mass and in normal intestinal tissue of i.c. tumor-bearing wild type mice. Tumor size in the wild-type mice was significantly higher than that in the cecum of IL-17A gene-knockout mice. Furthermore, anti-IL-17A monoclonal antibody treatment of wild-type mice resulted in decreased tumor size in the cecum. Model tumor-antigen-specific interferon-γ production was not modified in draining mesenteric lymph node cells in the absence or after neutralization of IL-17A. All the results suggest that constitutive expression of IL-17A in intestine enhances tumor growth, and anti-IL-17A antibody treatment is a candidate of a new anti-tumor immunotherapy against intestinal tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 217, Issue 1, January 2012, Pages 54-60
Journal: Immunobiology - Volume 217, Issue 1, January 2012, Pages 54-60
نویسندگان
Kiyotetsu Oshiro, Hideyasu Kohama, Masayuki Umemura, Catherine Uyttenhove, Kyoko Inagaki-Ohara, Takeshi Arakawa, Mamoru Harada, Susumu Nakae, Yoichiro Iwakura, Tadashi Nishimaki, Goro Matsuzaki,