کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10961773 | 1102012 | 2015 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of ketamine on the regional cerebral blood flow and binding index of the 5-HT2A receptor radioligand 123I-R91150 in the canine brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Ketamine, a dissociative anesthetic frequently used in veterinary medicine, possesses rapid-acting antidepressant effects in humans possibly indicating an interaction with the cerebral perfusion or with the serotonergic system. In this single-photon emission computed tomography study, 7 healthy dogs were used to investigate the influence of ketamine on the regional cerebral blood flow using technetium-99m-ethyl cysteinate dimer and on the binding of the 5-hydroxytryptamine 2A receptor radioligand iodine-123 labeled R91150 in the canine brain. Ketamine increased the regional perfusion in the left frontal cortex and right parietal cortex. Significant changes in the distribution of iodine-123 labeled R91150 were not observed. This study demonstrated an acute effect of ketamine on the regional brain perfusion but not on the 5-hydroxytryptamine 2A receptors in the canine brain in the dose used in this study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Veterinary Behavior: Clinical Applications and Research - Volume 10, Issue 4, JulyâAugust 2015, Pages 332-337
Journal: Journal of Veterinary Behavior: Clinical Applications and Research - Volume 10, Issue 4, JulyâAugust 2015, Pages 332-337
نویسندگان
Tim Waelbers, Ingeborgh Polis, Simon Vermeire, André Dobbeleir, Jos Eersels, Bart De Spiegeleer, Kurt Audenaert, Kathelijne Peremans,