Midazolam enhances the analgesic properties of dexmedetomidine in the rat

The combination of D + M administered IP to rats at doses of 0.12:20 and 0.09:15 mg kg−1 was shown to be a good combination to provide sedation/analgesia with a duration of action greater than 60 minutes. The onset of sedation was rapid (1-3 minutes), and onset of profound analgesia was reached within 5-10 minutes.