Observations of the potency and duration of vecuronium in isoflurane-anesthetized horses

A dose of 100 μg kg−1 VEC in isoflurane anesthetized horses failed to produce complete paralysis. The partial neuromuscular block lasted at least 2 hours after this dose had been administered. Edrophonium was required to reverse the neuromuscular block in three of four horses. It is likely that more than 100 μg kg−1 VEC would be necessary for complete neuromuscular blockade in horses, and that this dose will last >2 hours.