Comparison of two pre-anaesthetic medetomidine doses in isoflurane anaesthetized sheep

Intramuscular MED doses of 5 and 10 μg kg−1 reduced the propofol and isoflurane requirements for induction and maintenance of anaesthesia respectively. Cardiovascular variables and blood gas measurements remained stable over the course of anaesthesia but hypoxaemia developed in one of 16 sheep receiving MED.