Chlorins with (trifluoromethyl)phenyl substituents - Synthesis, lipid formulation and photodynamic activity against bacteria

Two chlorin derivatives bearing fluoro moieties were synthetized and their properties was evaluated. The quantum yields values of singlet oxygen formation are in the range of 0.45-0.69; fluorescence 0.20-0.31. Obtained chlorin derivatives were loaded into lipid vesicles and their photodynamic antibacterial potential was evaluated. It was noticed a log reduction of bacterial growth values for Enterococcus faecalis - 4.84, Staphylococcus aureus - 4.09 and Escherichia coli - 2.23.209