Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives

1bf shows better activity (IC50 = 4.56 μM) than EPZ004777 (IC50 = 35.19 μM). Intermediate 9a displays good activity (IC50 = 29.98 μM) and acceptable cytotoxicity (CC50 > 200 μM).147