Generation of an iPSC line of a patient with Angelman syndrome due to an imprinting defect

Resource tableUnique stem cell line identifierZIPi015-KAlternative name(s) of stem cell lineAS_ID, ZIP15InstitutionZentrum für integrative Psychiatrie, University Hospital Kiel, Kiel, GermanyContact information of distributorFranz-Josef Müller, franz-josef.mueller@uksh.deLaura Steenpass, laura.steenpass@uk-essen.deType of cell lineiPSCOriginhumanAdditional origin infoAge: 12Sex: femaleEthnicity if known: caucasianCell Sourceskin fibroblastsClonalityclonalMethod of reprogrammingepisomal/transgene-freeGenetic Modificationepigenetic aberration - imprinting defectType of Modificationlack of DNA methylation establishment or maintenance in the germ line of the patient's motherAssociated diseaseAngelman syndrome (OMIM #105830)Gene/locusPrader-Willi/Angelman syndrome locus, chromosome 15q11q13Method of modificationNAName of transgene or resistanceNAInducible/constitutive systemNADate archived/stock date14.04.2017 (Essen)Cell line repository/bankNAEthical approvalEthikkommission der medizinischen Fakultät der Christian-Albrechts Universität zu Kiel, Approval number A145/11A145/11