کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11015214 | 1788350 | 2019 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CDH17 alters MMP-2 expression via canonical NF-κB signalling in human gastric cancer
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کلمات کلیدی
CDH17NF-κBHER2MMP-2Short-interfering RNAEGFRCadherin-17MMP2CDH - HRCPI3K/AKT/mTOR - PI3K / AKT / mTORsiRNA - siRNAGastric cancer - سرطان معدهnuclear factor-kappaB - فاکتور هسته ای - kappaBnuclear factor-κB - فاکتور هسته ای κBmatrix metallopeptidase 2 - ماتریکس متالوپپتیداز 2cadherin - کادهرینEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمالHuman epidermal growth factor receptor-2 - گیرنده گیرنده فاکتور رشد اپیدرمی انسان 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Gastric cancer (GC), one of the most common cancers of the digestive system, results in high morbidity and mortality, but the molecular mechanisms underlying GC remain largely unknown. Cadherin-17 (CDH17) is a nonclassical member of the cadherin (CDH) superfamily of calcium-dependent proteins. Despite recent advances in the understanding of CDH17 biology, the mechanism of CDH17 in GC proliferation, migration, and invasion has not been extensively studied. In the present study, we observed that CDH17 expression was increased in GC tissues compared with para-carcinoma tissues and was correlated with lymph node metastasis and the AJCC stage. Additionally, a significant correlation was found between CDH17 protein expression and the number of blood and lymph vessels in GC tissues. Furthermore, in vitro suppression of CDH17 expression using short-interfering RNA (siRNA) decreased AGS cell proliferation, migration and invasion. Conversely, overexpression of CDH17 through plasmid transfection enhanced the malignant activity of AGS cells. Moreover, CDH17 increased the matrix metallopeptidase 2 (MMP-2) levels via the canonical nuclear factor-kappaB (NF-κB) pathway. Our findings offer new insights into the mechanism of the CDH17/NF-κB/MMP-2 axis, and the associated signalling pathways might represent novel targets for the treatment of GC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 682, 15 January 2019, Pages 92-100
Journal: Gene - Volume 682, 15 January 2019, Pages 92-100
نویسندگان
Xiao-jie Jiang, Jing Lin, Qing-he Cai, Jian-feng Zhao, Hui-jiao Zhang,