The inflammatory molecule sphingosine-1-phosphate is not effective to evoke or sensitize cough in naïve guinea pigs

We conclude that S1P was not efficient to evoke cough in awake naïve guinea pigs. S1P was also not effective to sensitize the cough evoked by stimulation of TRPV1 and TRPA1 receptors. Nonetheless it cannot be excluded that S1P influences cough in the context of inflamed airways when the cough-mediating nerves undergo sensory neuroplasticity.