کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11027407 | 1666295 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
iRNA(m6A)-PseDNC: Identifying N6-methyladenosine sites using pseudo dinucleotide composition
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: iRNA(m6A)-PseDNC: Identifying N6-methyladenosine sites using pseudo dinucleotide composition iRNA(m6A)-PseDNC: Identifying N6-methyladenosine sites using pseudo dinucleotide composition](/preview/png/11027407.png)
چکیده انگلیسی
As a prevalent post-transcriptional modification, N6-methyladenosine (m6A) plays key roles in a series of biological processes. Although experimental technologies have been developed and applied to identify m6A sites, they are still cost-ineffective for transcriptome-wide detections of m6A. As good complements to the experimental techniques, some computational methods have been proposed to identify m6A sites. However, their performance remains unsatisfactory. In this study, we firstly proposed an Euclidean distance based method to construct a high quality benchmark dataset. By encoding the RNA sequences using pseudo nucleotide composition, a new predictor called iRNA(m6A)-PseDNC was developed to identify m6A sites in the Saccharomyces cerevisiae genome. It has been demonstrated by the 10-fold cross validation test that the performance of iRNA(m6A)-PseDNC is superior to the existing methods. Meanwhile, for the convenience of most experimental scientists, established at the site http://lin-group.cn/server/iRNA(m6A)-PseDNC.php is its web-server, by which users can easily get their desired results without need to go through the detailed mathematics. It is anticipated that iRNA(m6A)-PseDNC will become a useful high throughput tool for identifying m6A sites in the S. cerevisiae genome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volumes 561â562, 15 November 2018, Pages 59-65
Journal: Analytical Biochemistry - Volumes 561â562, 15 November 2018, Pages 59-65
نویسندگان
Wei Chen, Hui Ding, Xu Zhou, Hao Lin, Kuo-Chen Chou,