کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11029601 | 1646482 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antiproliferative activity of podocarpane and totarane derivatives
ترجمه فارسی عنوان
سنتز و فعالیت ضد انعقادی مادیات پودوکارپان و توتارین
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The synthesis of podocarpanes, including the acetoxy phenol 23, isolated from Gaultheria yunnanensis and not previously synthesized, and totarane-type terpenoids, such as the catechol 28 and the ortho-quinone 27, starting from the natural labdane trans-communic acid is described. Their antiproliferative activities against MCF-7, T-84 and A-549 human tumoural cell lines are studied. The totarane o-quinone 27, and especially the catechol 28, which is readily oxidisable to compound 27, were the most active compounds. The results of the present study indicate that compound 28, at least, might be useful as an antitumoural agent.192
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 158, 5 October 2018, Pages 863-873
Journal: European Journal of Medicinal Chemistry - Volume 158, 5 October 2018, Pages 863-873
نویسندگان
Soumicha Mahdjour, Juan J. Guardia, Fernando RodrÃguez-Serrano, José Manuel Garrido, Isabel Blancas López-Barajas, Nuria Mut-Salud, Rachid Chahboun, Enrique Alvarez-Manzaneda,