Frames of reference and topological descriptions in Ayutla Mixe

► First account use of frames of reference (FoR) in Ayutla Mixe, a Mixe-Zoque language spoken in Southern Mexico is presented. ► Referential communication task was conducted with five pairs of native speakers to locate a figure with respect to a ground. ► The difference between projective and non-projective relations is discussed. ► The difference between landmark-based and direct FoRs, particularly when the anchor is a speech act participant is debated.