A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR), Serotonin 2C Receptor (5-HT2CR) and Sensation Seeking

Association between different sensation seeking traits and related phenotypes with a serotonin transporter gene promoter polymorphism (5-HTTLPR) and serotonin 2C receptor (5-HT2CR) was studied in the male sample (university students, 16-26 years old). Sensation seeking traits correlated with Big 3 personality traits (Extraversion, Psychoticism, Neuroticism) and temperament traits (Novelty seeking and Harm avoidance). Polymorphism of 5-HTTLPR did not account for individual differences in personality traits but was associated with variation in Thrill and Adventure Seeking for everyday activities. Polymorphism of 5-HT2CR was related to individual differences in Boredom Susceptibility.