کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11263155 | 1777900 | 2019 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microfabrication of pH-responsive 3D hydrogel structures via two-photon polymerization of high-molecular-weight poly(ethylene glycol) diacrylates
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
3D pH-responsive microstructures by two-photon lithography (2âPL) in poly(ethylene glycol) diacrylates (PEG-DAs) hydrogels are particularly suitable for biosensing as structural and functional components. So far, 2âPL patterning of hydrogels have been successfully achieved only for low molecular-weight (⤠700âDa MMw) PEG-DAs, which is unfortunately not mechanically compliant with single cell and tissues stiffness. We report an optimised protocol to setup a 2âPL fabrication of high MMw (10âkDa) PEG-DA-based formulations, suitable for pH sensing in soft biological tissues. Two different shapes (pyramids and domes) were obtained and tested for mechanical characterization and pH responsiveness at the microscale. Fast pH-induced swelling (<15âmin) in microstructures allows for envisioning high MMw PEG-DA-based micro and nanostructures via 2âPL as a tunable pH responsive tool for biosensing applications in cell and tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 279, 15 January 2019, Pages 418-426
Journal: Sensors and Actuators B: Chemical - Volume 279, 15 January 2019, Pages 418-426
نویسندگان
Elisa Scarpa, Enrico Domenico Lemma, Roberto Fiammengo, Maria Pia Cipolla, Ferruccio Pisanello, Francesco Rizzi, Massimo De Vittorio,