کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1139345 1489418 2014 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In search for an accurate model of the photosynthetic carbon metabolism
ترجمه فارسی عنوان
در جستجوی یک مدل دقیق متابولیسم کربن فتوسنتز
کلمات کلیدی
چرخه کالوین-بنسون، متابولیسم کربن، رتبه بندی مدل، معادلات دیفرانسیل و جبری
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی کنترل و سیستم های مهندسی
چکیده انگلیسی

The photosynthetic carbon metabolism, including the Calvin–Benson cycle, is the primary pathway in C3-plants, producing starch and sucrose from CO2. Understanding the interplay between regulation and efficiency of this pathway requires the development of mathematical models which would explain the observed dynamics of metabolic transformations. Here, we address this question by casting the existing models of Calvin–Benson cycle and the end-product processes into an analysis framework which not only facilitates the comparison of the different models, but also allows for their ranking with respect to chosen criteria, including stability, sensitivity, robustness and/or compliance with experimental data. The importance of the photosynthetic carbon metabolism for the increase of plant biomass has resulted in many models with various levels of detail. We provide the largest compendium of 15 existing, well-investigated models together with a comprehensive classification as well as a ranking framework to determine the best-performing models for metabolic engineering and planning of in silico experiments. The classification can be additionally used, based on the model structure, as a tool to identify the models which match best the experimental design. The provided ranking is just one alternative to score models and, by changing the weighting factor, this framework also could be applied for selection of other criteria of interest.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematics and Computers in Simulation - Volume 96, February 2014, Pages 171–194
نویسندگان
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