کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1139788 | 956695 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mathematical analysis of an HIV model with impulsive antiretroviral drug doses
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
کنترل و سیستم های مهندسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mathematical analysis of an HIV model with impulsive antiretroviral drug doses Mathematical analysis of an HIV model with impulsive antiretroviral drug doses](/preview/png/1139788.png)
چکیده انگلیسی
In this paper, we incorporate the periodic therapy from antiretroviral drugs for HIV into the standard within-host virus model, and study the stability and bifurcation of the system. It is shown that when the basic reproduction number of virus is less than one, there is an infection-free equilibrium which is globally stable. Further, if it is greater than one, the HIV infection is uniformly persistent. Besides, subharmonic bifurcation occurs under suitable conditions, and chaotic attractor may emerge through period doubling routes, which can be used to explain the HIV patients’ unpredictable unstable health states, even after a long and hard treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematics and Computers in Simulation - Volume 82, Issue 4, December 2011, Pages 653–665
Journal: Mathematics and Computers in Simulation - Volume 82, Issue 4, December 2011, Pages 653–665
نویسندگان
Ting Gao, Wendi Wang, Xianning Liu,