کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1140897 1489432 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A viral infection model with periodic immune response and nonlinear CTL response
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی کنترل و سیستم های مهندسی
پیش نمایش صفحه اول مقاله
A viral infection model with periodic immune response and nonlinear CTL response
چکیده انگلیسی

This paper investigates a viral infection model with periodic immune response and nonlinear cytotoxic T lymphocyte (CTL) response. Using the periodic rhythms of human immune system, the model can avoid the unreasonable equilibrium in the basic viral model with nonlinear CTL response introduced by Nowak et al. We obtain the global stability of the infection-free equilibrium and the immune-exhausted equilibrium. Numerical simulations show that the oscillation of immune system can affect the pattern of the viral dynamical behaviors. Period doubling bifurcations of the system are observed via simulations. This can provide a possible interpretation for the viral oscillation behaviors, which were observed in chronic HBV and HCV infection patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematics and Computers in Simulation - Volume 80, Issue 12, August 2010, Pages 2309–2316
نویسندگان
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