کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1172971 1491353 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multichannel quartz crystal microbalance array: Fabrication, evaluation, application in biomarker detection
ترجمه فارسی عنوان
آرایه میکروبازکی کریستال چند کاناله: ساخت، ارزیابی، کاربرد در تشخیص بیومارکر
کلمات کلیدی
آرایه میکروبازار کریستال چند کاناله، استون، اکسید نیتریک، نانولوله کربنی چند ضلعی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی

A multichannel quartz crystal microbalance array (MQCM) with three pairs of gold electrodes was fabricated for detection of two biomarkers: acetone and nitric oxide (NO). The gold electrodes were deposited symmetrically on an AT-cut 10 MHz circular quartz plate using photolithography, sputtering, and lift-off technologies. The effect of gold layer thickness on MQCM performance was investigated and the optimized thickness was 101 nm. The simulation values of the electric parameters C0, Cq, Lq, and Rq in the Butterworth–Van Dike equivalent circuit for the MQCM device were 97 pF, 1.3 pF, 1.05 mH, and 9.8 Ω, respectively. Simulation values were in the theoretical range, which indicated that the fabricated MQCM device had good resonance performance. Two types of nanocomposites, titanium dioxide–multiwalled carbon nanotubes and cobalt (II)phthalocyanine–silica, were synthesized as sensing materials. The sensing mechanism is based on coordination adsorption of target molecules onto the sensing material, resulting in a resonant frequency shift of modified QCM sensor. A linear range from 4.33 to 129.75 ppmv for acetone was obtained and one from 5.75 to 103.45 ppbv for NO.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 494, 1 February 2016, Pages 85–92
نویسندگان
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