A methodological approach to the selection of liquid reagents for chemical ionization ion trap-gas chromatography mass spectrometry: A case study of GBL and 1,4-BD

- IT-MS improved reaction times to 104-105 times higher than conventional CI sources.
- In situ IT-MS allowed the use of vapors from liquid reagents as CI gas.
- The use of liquid CI reagents can greatly affect ionization specificity.
- CI spectra analysis, slopes and LOD evaluation for checking the method performances.
- Comprehensive approach is useful for the choice of appropriate CI reagent.