کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1192886 1492302 2011 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IR spectroscopy of isolated metal–organic complexes of biocatalytic interest: Evidence for coordination number four for Zn2+(imidazole)4
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
IR spectroscopy of isolated metal–organic complexes of biocatalytic interest: Evidence for coordination number four for Zn2+(imidazole)4
چکیده انگلیسی

The characterization of the interactions of Zn2+ ions with imidazole ligands is vital for understanding the function of a plethora of zinc enzymes at the molecular level. The infrared multiple photon dissociation (IRMPD) spectrum of mass selected Zn2+(imidazole)4 cations, [ZnIm4]2+, was obtained in the 670–1840 cm−1 fingerprint range by coupling the infrared free electron laser (IR-FEL) at the Centre Laser Infrarouge d’Orsay (CLIO) with a quadrupole ion trap mass spectrometer equipped with an electrospray ionization (ESI) source. The experimental efforts are complemented by quantum chemical calculations for [ZnImn]2+ with n = 1–4 at the B3LYP level using basis sets ranging from cc-pVDZ to aug-cc-pVTZ. By comparison with calculated linear absorption spectra, the transitions observed in the IRMPD spectrum are assigned to vibrational modes of the imidazole ligands. In combination, the experimental data and the calculations provide detailed information about structure, metal–ligand bonding, charge distribution, and binding energy of the [ZnIm4]2+ complex in the gas phase. The superior abundance of the n = 4 complex of [ZnImn]2+ in the mass spectra of the ESI source is indicative of the preferred coordination number CN = 4 for Zn2+ interacting with imidazole ligands in both the gas and the liquid phase. Comparison of the IR spectra of [ZnImn]2+ with that of bare Im reveals the impact of the strong Zn2+–Im interaction on the electronic, geometric, and vibrational structure of the aromatic ligands upon sequential filling of the first coordination shell. Comparison with the structural and vibrational properties of the imidazole cation demonstrates that the metal-to-ligand charge transfer in [ZnImn]2+ is dominated by σ donation, whereas contributions from π donation are minor.

Figure optionsDownload high-quality image (186 K)Download as PowerPoint slideHighlights
► IR spectroscopic and mass spectrometric characterization of [ZnIm4]2+ complexes.
► First experimental characterization of Zn2+–imidazole interaction in the gas phase.
► Evidence for tetrahedral coordination number CN = 4 in [ZnImn]2+ complexes.
► Systematic trends of Zn2+–Im interaction in [ZnImn]2+ complexes with n = 1–4.
► Biochemical implications for Zn enzymes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Mass Spectrometry - Volume 308, Issues 2–3, 1 December 2011, Pages 316–329
نویسندگان
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