کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1192989 | 1492271 | 2013 | 10 صفحه PDF | دانلود رایگان |
• Microscope mode imaging mass spectrometry (IMS).
• Application of a velocity corrected ion extraction.
• Tuneable IMS for optimized imaging properties.
• Improved time of flight resolution for linear IMS.
• Imaging samples of up to 5 mm in one experiment.
Microscope mode imaging mass spectrometry requires that ions created in a desorption process are focussed both spatially and according to their mass-to-charge ratio, m/z, onto the plane of an imaging detector. However, it is generally difficult to find techniques that optimize both of these parameters simultaneously. The use of pulsed electric fields allows a second order focussing of the ions according to their m/z value, whilst limiting the loss of spatial resolution, albeit over a limited mass range. Here we present a simple method for rescaling the parameters in a pulsed extraction experiment in order to access different mass ranges, whilst still achieving the benefits of simultaneous optimization of mass and spatial resolutions.
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Journal: International Journal of Mass Spectrometry - Volume 356, 15 December 2013, Pages 14–23