کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1193697 | 1492343 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A theoretical and mass spectrometry study of the novel mechanism of N-glycosidic bond cleavage in nucleoside
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The fragmentation pathways of ribonucleosides, deoxynucleosides and isopropylidenenucleosides were investigated by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in both positive and negative mode. Novel fragmentation pathways investigated using deuterium-label experiment provided important insight on the nature of N-glycosidic bond cleavage. The deuterium of 5′-hydroxyl group on ribose moiety was deprived by the nucleobase, and a novel five-member ring through 5′-oxygen and 1′-carbon was formed in the ribose residue as the lost neutral molecule, instead of a new double bond generating between 1′-C and 2′-C as the literature reported. The novel fragmentation pathway was supported by density functional theory calculations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Mass Spectrometry - Volume 282, Issues 1–2, 15 April 2009, Pages 1–5
Journal: International Journal of Mass Spectrometry - Volume 282, Issues 1–2, 15 April 2009, Pages 1–5
نویسندگان
Jihong Liu, Shuxia Cao, Bin Jia, Donghui Wei, Xincheng Liao, Jiansha Lu, Yufen Zhao,