کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1227206 | 968355 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, characterization and cytotoxic/cytostatic activity of La(III) and Dy(III) complexes
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis, characterization and cytotoxic/cytostatic activity of La(III) and Dy(III) complexes Synthesis, characterization and cytotoxic/cytostatic activity of La(III) and Dy(III) complexes](/preview/png/1227206.png)
چکیده انگلیسی
New La(III) and Dy(III) complexes of deprotonated 4-hydroxy-3[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one (Acenocoumarol) were synthesized and characterized using FT-IR, FT-Raman, 1H NMR spectra, and elemental analyses. The ligand and its lanthanide(III) complexes were tested for their cytotoxic/cytostatic activity against two tumor cell lines and peritoneal mouse macrophages. The La(III) and Dy(III) complexes exhibit good activity against melanoma B16 and fibrosarcoma L929 and they are stronger inhibitors of tumor cell proliferation compared to the ligand without influencing normal cell viability and NO release by mouse peritoneal macrophages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 24, Issue 1, January 2010, Pages 7-13
Journal: Journal of Trace Elements in Medicine and Biology - Volume 24, Issue 1, January 2010, Pages 7-13
نویسندگان
Irena Kostova, Tsvetanka Stefanova,