کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1227375 1645361 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability
چکیده انگلیسی

ProjectThe opportunistic fungal Candida albicans can produce superficial and systemic infections in immunocompromised patients. An essential stage to both colonization and virulence by C. albicans is the transition from budding yeast form to filamentous form, producing biofilms.ProcedureIn this work, we studied the effect of the organochalcogenide compound (PhSe)2 on both cell growth and biofilm formation by C. albicans.Results(PhSe)2 inhibited both growth and biofilm formation by C. albicans. The inhibitory effects of (PhSe)2 depended on the cell density and (PhSe)2 concentration. We have also observed that (PhSe)2 stimulated ROS production (67%) and increased cell membrane permeability (2.94-fold) in C. albicans. In addition, (PhSe)2 caused a marked decrease in proteinase activity (6.8-fold) in relation to non-treated group.Conclusions(PhSe)2 decreased both cell growth and biofilm development, decreasing the release of extracellular proteinases, which is an important facet of C. albicans pathogenicity. The toxicity of (PhSe)2 towards C. albicans can be associated with an increase in ROS production, which can increase cell permeability. The permanent damage to the cell membranes can culminate in cell death.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 29, January 2015, Pages 289–295
نویسندگان
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