Study of the efficiency of new phenoxo-ether titanium (IV) complexes as catalysts in asymmetric epoxidation processes. Comparison of HPLC and CE chiral methodologies

The efficiency as catalysts in asymmetric epoxidation of cinnamyl alcohol, of a new family of phenoxo-ether titanium complexes synthesized by our research team has been studied. The influence of the metal environment and the presence of chiral moieties in the molecule on the efficiency of the studied catalysts has been investigated. The study of the catalytic activity of these compounds in the asymmetric epoxidation process has been carried out at − 20 °C with a catalyst/substrate/tert-butylhydroperoxide ratio of 1/2/4 and 1/20/40 using dichloromethane as solvent. For routine determination of the enantiomeric excess obtained in these processes, chiral HPLC and CE methodologies previously developed by our research team were applied. Results obtained for both methods were statistically compared in order to show that there were no significant differences between them.