Design, Synthesis and Synergistic Effects of Novel Derivatives of Solanesol*

To further explore the biological activities of solanesylamine derivatives, several novel solanesylpiperazinotriamines and their amides were designed and synthesized, the chemical structures of target compounds were confirmed by IR, 1H NMR, MS, and element analysis. The in vitro antitumor activities of the synthetic compounds were assessed by MTT test on L1210 and CHO cells. The preliminary results showed that at low micromolar concentrations these compounds exhibit obvious toxicity against tumor cells, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations, they also evidently enhance the curative effect of vincristine(VCR). The synergistic effects of compounds 4a, 4c, and 9 were even superior to that of reference compound N,N′-bis(3,4-dimethoxybenzyl)-N-solanesyl-ethylenediamine(SDB).