Biologically active diorganotin(IV) complexes of N-(2-hydroxy-3-isopropyl-6-methyl benzyl) glycine

A new series of diorganotin(IV) complexes of general formula [Ph2Sn(OPri)(Hhbgl)] (1), [Ph2Sn(Hhbgl)2] (2), [Bu2Sn(OPri)(Hhbgl)] (3), [Bu2Sn(Hhbgl)2] (4), [Me2Sn(OPri)(Hhbgl)] (5), and [Me2Sn(Hhbgl)2] (6) [where H2hbgl = N-(2-hydroxy-3-isopropyl-6-methyl benzyl) glycine] were synthesized by reacting diorganotin(IV) chloride with the ligand, with the aid of sodium iso-propoxide in appropriate stoichiometric ratios (1:1 and 1:2). All the six complexes were tested in vitro for their antibacterial activity against Gram-positive bacteria namely, Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121 and two Gram-negative bacteria namely, Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741 and in vitro antifungal activity against three pathogenic fungal strains namely, Aspergillus niger, Aspergillus flavus and Penicillium sp.