کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1252708 1496032 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adsorptive square wave voltammetric determination of the antiviral drug valacyclovir on a novel sensor of copper microparticles–modified pencil graphite electrode
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Adsorptive square wave voltammetric determination of the antiviral drug valacyclovir on a novel sensor of copper microparticles–modified pencil graphite electrode
چکیده انگلیسی

To overcome the well-known problems encountered with surface fouling of carbon electrodes that occurred with many compounds, we report a simple and rapid method for the preparation of a disposable sensor depending on electrodeposition of porous Cu-microparticles on pencil graphite electrode (Cu-PGE) that can be applied for sensing antiviral compound valacyclovir (VAL). The bare and porous Cu-modified pencil graphite electrodes were characterized by cyclic voltammetry and SEM. The porous Cu-modified pencil graphite electrode displayed distinct electrocatalytic activities in response to the electrochemical redox reaction of Cu2+ ion in the Cu-VAL complex. Adsorptive square wave stripping voltammetry (AdSWV) was used for the direct electrochemical determination of VAL. Under experimental conditions, the modified electrode had a linear response range from 2.0 × 10−9 M to 1.0 × 10−8 M VAL with a detection limit of 1.78 × 10−10 M. The procedure was applied to the assay of VAL in tablets with mean percentage recoveries of 100.28%. The porous Cu-modified pencil graphite electrode (Cu-PGE) is fabricated utilizing a simple single method, and at an extremely low cost with high stability, sensitivity and offering a promising tool for sensing VAL in quality control laboratories and in stability studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Issue 1, January 2016, Pages 143–151
نویسندگان
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