کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1252842 1496043 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticancer and antimicrobial evaluation of newly synthesized steroidal 5,6 fused benzothiazines
ترجمه فارسی عنوان
ارزیابی ضد میکروبی و ضد میکروبی از سنتز شده 5.6 سنتز بنزوتیایزین
کلمات کلیدی
بنزوتیازین، 5α-کلستان-6-یک، ضد باکتری، ضد قارچ، ضد سرطان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

A series of new 5α-cholestano [5,6-b] benzothiazines (4–6) has been synthesized by the reaction of 5α-cholestan-6-one (1–3) with 2-aminothiophenol in the presence of iodine. The structures of newly synthesized compounds have been established on the basis of spectral and analytical data. Compounds (1–6) were screened for in vitro anticancer activity against the human cancer cell lines; SW480 (colon adenocarcinoma cells), A549 (lung carcinoma cells), HepG2 (hepatic carcinoma cells) and HeLa (cervical cancer cells) using MTT assay during which the products (4–6) showed marked increase in anticancer activity and in particular, compound 6 showed IC50 = 13.73 μmol L−1 against HeLa cells, being more effective than Doxorubicin against the same cells. Compounds 4 and 6 also showed minimum IC50 of 15.83 μmol L−1 and 16.89 μmol L−1 against HepG2 and A549 cells, respectively. Compounds (1–6) were also tested for in vitro antimicrobial activity against different bacterial as well as fungal strains during which newly synthesized compounds (4–6) were found more potent than starting compounds (1–3). Compound 4 was found to be more potent than the reference drug, Chloramphenicol, in the case of Escherichia coli while compound 5 was found almost equally potential antifungal agent against P. marneffei in comparison with the reference drug, Nystatin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 7, Issue 4, September 2014, Pages 461–468
نویسندگان
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