کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1253215 | 971080 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel Method for the Enantioselective Synthesis of β-Lactams
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel Method for the Enantioselective Synthesis of β-Lactams Novel Method for the Enantioselective Synthesis of β-Lactams](/preview/png/1253215.png)
چکیده انگلیسی
A novel method for the enantioselective synthesis of β-lactams is described in this study. 2,3-Dihydrobenzooxazin-4-one derived from salicylamide and L-menthone was used as the chiral auxiliary, which reacted with α-bromo-acyl bromides in the presence of pyridine to give carboximides 2. The stereo-controlled Reformatsky-type reactions of carboximides with imines yielded the corresponding trans β-lactams with high enantioselectivities(e.e. 75%-86%) and high chemical yields(63%-85%), meanwhile, the chiral auxiliary dihydrobenzooxazin-4-one was released and recovered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Research in Chinese Universities - Volume 24, Issue 1, January 2008, Pages 58-64
Journal: Chemical Research in Chinese Universities - Volume 24, Issue 1, January 2008, Pages 58-64
نویسندگان
Qing YUAN, Shan-zhong JIAN, Yan-guang WANG,