کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1260605 971750 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization, and biological properties of nano-rare earth complexes with L-glutamic acid and imidazole
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis, characterization, and biological properties of nano-rare earth complexes with L-glutamic acid and imidazole
چکیده انگلیسی

Four nano-rare earth ternary complexes of L-glutamic acid and imidazole RE(Glu)3ImCl3·3H2O (RE=Ce3+, Pr3+, Sm3+, Dy3+, Glu= L-glutamic acid, and Im=imidazole) were synthesized. Their composition was characterized with elemental analysis, IR, and molar conductance. The TEM image indicated that the complexes were regular shaped and the length was about 30∼60 nm. The antibacterial activity test showed that all these complexes exhibited better antibacterial ability against Escherichia coli, Staphylociccus aureus, and Candida albican (MIC were about 180, 100, and 310 μg/ml, respectively) and could be considered as broad-spectral antimicrobial. Their antitumor activity in vitro against leukemia K562 cells was measured using the MTT method. The results indicate that the four complexes possess strong inhibition effect on leukemia K562 cells. An approximately linear relationship is discovered between the relative inhibition rate and concentration, with the correlation coefficients R>0.7 and P<0.05, which is considered statistically significant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Rare Earths - Volume 26, Issue 4, August 2008, Pages 473-477