کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1265394 972217 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ultrasound-promoted synthesis of novel bipodal and tripodalpiperidin-4-ones and silica chloride mediated conversion to its piperidin-4-ols: Synthesis and structural confinements
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Ultrasound-promoted synthesis of novel bipodal and tripodalpiperidin-4-ones and silica chloride mediated conversion to its piperidin-4-ols: Synthesis and structural confinements
چکیده انگلیسی

The ultrasound-promoted synthesis of novel bipodal and tripodalpiperidin-4-ones was carried out by the reaction of 4-piperidone hydrochloride monohydrate with different alkylating and acylating agents. It was preferably reduced to respective piperidin-4-ols by ultrasonic irradiation using silica chloride, which maintains higher yields by acting as an effective supporting polymer. The sterically hindered phthaloyl derivative of piperidin-4-one was synthesized by ultrasonic irradiation which was difficult by conventional methods.

Figure optionsDownload as PowerPoint slideHighlights
► Novel bipodal, tripodalpiperidin-4-ones were synthesized under sonication.
► High percentage of yields was found under sonication than the conventional methods.
► Piperidin-4-ones were reduced using silica chloride/NaBH4 with higher yields.
► Silica chloride/NaBH4 works as an effective catalyst for reduction under sonication.
► Sterically hindered phthaloyl piperidin-4-one was also achieved under sonication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics Sonochemistry - Volume 19, Issue 3, May 2012, Pages 522–531
نویسندگان
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