Efficient sonochemical synthesis of alkyl 4-aryl-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate derivatives

A facile, efficient and environment-friendly protocol for the synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives has been developed by the convenient ultrasound-mediated reaction of 2(1H)pyridone derivatives with the Vilsmeier–Haack reagent. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.

► Ultrasonic-assisted synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives.
► The ultrasound irradiation accelerates the reaction rate greatly under mild conditions.
► Better reaction times than conventional methods.