کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1265457 | 972222 | 2012 | 7 صفحه PDF | دانلود رایگان |
An intramolecular direct arylation of various aryl bromides was performed using ultrasonic irradiation and a continuous flow capillary microreactor. The present procedure provided a higher functional group tolerance, ligand-free, milder reaction conditions and a shorter reaction time for the direct arylation compared with the conventional methods. The ultrasonic irritation not only greatly promoted the conversion and selectivity of the direct arylation, but also solved the clogging problem of the microreactor for solid-forming reaction and made the reaction run smoothly.
► Intramolecular direct arylation was achieved under ultrasound irradiation in a capillary microreactor.
► The arylation procedure was ligand free, low temperature and had broad substrate scope.
► The arylation gave a better yield and selectivity than conventional one.
► Solving the clogging problem of microreactor.
Journal: Ultrasonics Sonochemistry - Volume 19, Issue 2, March 2012, Pages 250–256