Relevance of sonochemistry or ultrasound (US) as a proficient means for the synthesis of fused heterocycles

• Sonochemistry dramatically reduced reaction times, from days or hours to minutes.
• Sonochemistry also provides higher yields, lower cost, easy workups and greater purity.
• This method is more convenient and can be easily controlled.
• It provides selectivity, ease of experimental manipulation and enhanced reaction rates.
• Sonochemistry offers process related and environmental advantages.

Medicinal chemistry has been benefited by combinatorial chemistry and high throughput parallel synthesis. The use of sonochemistry under controlled conditions has been proved beneficial for medicinal chemistry and drug discovery process since it dramatically reduces reaction times, from days or hours to minutes. In addition, sonochemistry synthesis provides higher yields, lower cost, easy workups and greater purity as compared to lower yields, tedious workups, longer reaction times, lesser purity and termination of many by-products in the conventional thermal methods.