Ultrasound assisted synthesis of tetrahydrobenzo[c]xanthene-11-ones using CAN as catalyst

Tetrahydrobenzo[c]xanthenes-11-ones was synthesized by a three component reaction of α-naphthol, aromatic aldehyde and dimedone. Ceric ammonium nitrate acts as a suitable eco-friendly catalyst for this method. Shorter reaction duration, mild reaction condition and low cost make this protocol more effective.

► Synthesis of “bioactive molecules” by following the “Green Chemistry Norms”.
► Ultrasound accelerates the synthesis of tetrahydrobenzo[c]xanthene-11-ones.
► The reaction involves use of an eco-friendly catalyst – CAN.
► Novel method of synthesis of tetrahydrobenzo[c]xanthene-11-ones from α-naphthol.
► A probable mechanism through ortho-Quinone Methides intermediates is proposed.